Promising Mesothelioma Treatment with PORT-7

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News Summary

Portage Biotech Inc. has revealed groundbreaking preclinical data on PORT-7, a selective adenosine A2B receptor inhibitor, during the 2025 European Lung Cancer Congress. Demonstrating over 90% inhibition of tumor growth in murine models, this new therapy could transform outcomes for mesothelioma patients. Combined with PORT-6, it aims to enhance immunotherapy effectiveness. As clinical trials approach, this milestone highlights the urgent need for innovative treatments in an area with limited options.

Breakthrough in Mesothelioma Treatment: Promising Results from Innovative Drug

March 27, 2025 – In a remarkable development for the treatment of mesothelioma, Portage Biotech Inc. has unveiled new preclinical data that could shift the landscape for patients battling this aggressive cancer. The findings, shared at the recent 2025 European Lung Cancer Congress in Paris, highlight the potential of PORT-7 (TT-4), a selective adenosine A2B receptor inhibitor.

Stunning Efficacy Demonstrated in Murine Models

The data draws attention to the significant activity of PORT-7 not only as a single agent but also in conjunction with an anti-PD1 antibody. In murine models, the combination therapy exhibited a dramatic over 90% inhibition of tumor growth. This impressive figure suggests that PORT-7 could offer fresh hope to patients, especially those who have seen little success with current treatment options.

Immunohistochemistry analyses of the tumor samples revealed a robust infiltration of immune effector cells, specifically CD3 and CD45 positive cells. This highlights not just a reduction in tumor size but an enhanced immune response, a critical factor in the fight against mesothelioma.

A New Frontier in Immunotherapy

Mesothelioma is notoriously resistant to conventional treatments. With very few effective options currently available, the need for innovative therapeutic approaches has never been more pressing. The results presented are notable as it marks the first instance of antitumor activity against mesothelioma using a selective A2B receptor inhibitor. This paradigm shift in treatment could pave the way for more effective immunotherapeutic options.

Upcoming Clinical Trials on the Horizon

In addition to the promising data on PORT-7, Portage Biotech is making arrangements to initiate a first-in-human clinical trial with this innovative therapy. This next step emphasizes the company’s commitment to transforming the treatment landscape for mesothelioma patients.

A Combined Approach with PORT-6

While PORT-7 is gaining attention, Portage is also advancing the development of PORT-6, a highly selective A2A adenosine receptor inhibitor. The strategic plan is to co-administer these two agents in an ongoing trial known as ADPORT-601. This will be a historic moment, as it represents the first known usage of two selective A2A and A2B antagonists together in a clinical setting.

The intent behind this combined approach is to fully neutralize adenosine-mediated immunosuppression within the tumor microenvironment, thereby boosting the body’s anti-tumor responses. The synergistic effect of these medications holds the promise of broadening the impact of immunotherapy on solid tumors.

About Portage Biotech

Portage Biotech is a clinical-stage immuno-oncology firm that is focused on advancing a pipeline of novel biologics designed to enhance the immune system’s capacity to combat cancer. Their ongoing efforts reflect a commitment to innovation and the pursuit of effective cancer treatments.

Looking Forward

While the news is encouraging, it is important to remain sensible about expectations. As development continues, uncertainties remain about securing financing, and the scientific results may diverge from projections. However, the enthusiasm surrounding Portage Biotech’s advancements presents a beacon of hope for mesothelioma patients and their loved ones.

For those awaiting new treatment options, this research exemplifies a promising direction in clinical cancer therapies. If further phases of trials yield positive results, the incorporation of PORT-7 into treatment regimens may significantly alter the prognosis for many afflicted by this formidable disease.