Testicular mesothelioma
Mesothelioma of the tunica vaginalis is a very rare tumor that starts in the covering layer of the testicles. It is often called testicular mesothelioma.
Last reviewed October 27, 2026 against the sources listed at the end of this page.
In short
- Possible symptoms: swelling of a testicle or the scrotum, a lump, or a feeling of heaviness.
- Because the symptoms look like common, harmless conditions, it may not be suspected until tissue is examined in the lab.
- Because it is so rare, a pathology review at an experienced center is often recommended.
Symptoms
The American Cancer Society lists these possible symptoms of mesothelioma of the tunica vaginalis:
- swelling of a testicle or of the scrotum
- a lump in the testicle or scrotum
- a feeling of heaviness or fullness in the scrotum
These symptoms are far more often caused by other conditions, such as a hydrocele (a collection of fluid around the testicle). Any new lump or swelling should still be checked by a doctor.
How it is found
Because the symptoms look like common, harmless conditions, this cancer may not be suspected until tissue removed during surgery is examined in the lab. The diagnosis is confirmed by a pathologist. Given how rare it is, asking for a second review of the slides by a pathologist experienced with mesothelioma is reasonable.
Treatment
There is no formal staging system. Treatment usually starts with surgery, and the care team decides whether more treatment is needed based on the pathology and scans. Because few doctors see more than a handful of cases, an opinion from a cancer center with mesothelioma experience can help. See finding a treatment center.
Exposure
Asbestos exposure is a recognized risk factor for mesothelioma in general, according to NCI. As with other types, a written history of jobs, military service, and homes is the most useful record to start for your doctors and for any claim.
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Start the free reviewThis page is general health information, summarized from the sources below. It is not medical advice. Talk with your own doctor or care team about your situation.